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Filtered Search Results
eMolecules 371935-79-4 | Medchem Express | PI-103 (Hydrochloride) | 5mg | 446256532 | HY-10115A | MFCD10687102 | 384.82 | C19H17ClN4O3
Ambeed | 3-Chloro-5-fluorobenzamide | 250mg | 552730460 | A435740 | 874781-06-3 | MFCD03407964 | 173.570 | C7H5ClFNO
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Apexbio Technology LLC Thiamine HCl (Vitamin B1) 67-03-8 10mM (in 1mL H20)
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Thiamine HCl (Vitamin B1) (67-03-8) is a water-soluble micronutrient and biological precursor involved in coenzyme-dependent metabolic pathways It undergoes phosphorylation in cells to form thiamine pyrophosphate (TPP) which participates in carbohydrate metabolism through enzymatic reactions involving pyruvate dehydrogenase alpha-ketoglutarate dehydrogenase and branched-chain alpha-keto acid dehydrogenase complexes Thiamine HCl exerts its biological activity primarily through serving as a precursor to the coenzyme TPP enabling regulation of carbohydrate metabolic pathways In vitro assays frequently apply thiamine HCl to investigate enzyme activity regulation and coenzyme-dependent processes however clearly reported IC50 values are not specified due to its principal function as a coenzyme precursor Based on these attributes thiamine HCl holds research potential in studies of cellular energetics neuronal function and metabolic processes
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5000712352 GUVACINE ETHYL ESTER 25MG
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Aobchem AOBCHEM
5000862888 ETHYL 2 6-DIBROMONICOTINATE 5G
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5000429300 FAST RED VIOLET LB 250MG
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Medchemexpress LLC Carbonyl cyanide (m-chlorophenyl)hydrazone | 555-60-2 | MFCD00001848 | >=97.0% | 204.61 g/mol | C9H5ClN4 | 250 MG
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CCCP (carbonyl cyanide m-chlorophenylhydrazone) is a mitochondrial oxidative phosphorylation (OXPHOS) uncoupler used in research to depolarize mitochondrial membranes and disrupt cellular respiration. It is commonly applied to study mitophagy and mitochondrial quality-control pathways, for example inducing PINK1 activation and Parkin Ser65 phosphorylation.
- Causes rapid mitochondrial membrane depolarization
- Induces PINK1 activation and Parkin Ser65 phosphorylation for mitophagy studies
- Useful to perturb cellular respiration and study reactive oxygen species production
- Provided as a high-purity research reagent for laboratory experiments
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Medchemexpress LLC Copanlisib dihydrochloride | 1402152-13-9 | C23H30Cl2N8O4 | 50 MG
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Copanlisib dihydrochloride is a potent, selective, and ATP-competitive pan-class I PI3K inhibitor. It exhibits IC50 values of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ. This compound demonstrates superior antitumor activity and shows over 2,000-fold selectivity against other lipid and protein kinases, with the exception of mTOR.
- Induces apoptosis in a subset of tumor cell lines resistant to certain treatments.
- Shows complete inhibition of PI3K-mediated AKT phosphorylation in ELT3 cells at 5 nM.
- Potently inhibits cell proliferation in various human tumor cell lines, particularly those with PIK3CA-activating mutations or HER2-positive.
- Significantly increases caspase-9 activities and levels of phosphorylated p53 at Ser15 and cleaved PARP in BT20 breast cancer cells.
- Demonstrates robust antitumor activity in rat KPL4 tumor xenograft models, with high tumor growth inhibition rates.
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Apexbio Technology LLC Dasatinib Monohydrate 863127-77-9 100mg
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Dasatinib Monohydrate (CAS 863127-77-9) is a small molecule inhibitor primarily targeting Bcr-Abl and Src family tyrosine kinases with IC50 values of 3 0 nM and 0 55 nM respectively It acts as an ATP-competitive inhibitor and demonstrates broad-spectrum antiproliferative activity in both hematological and solid tumor cell models Dasatinib is effective in suppressing wild-type and the majority of imatinib-resistant BCR-ABL kinase variants In murine studies oral administration of dasatinib reduced disease progression and bioluminescence levels in BCR-ABL-driven leukemia models Dasatinib is widely employed in research on kinase signaling and drug resistance mechanisms in Ph-positive leukemias
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eMolecules 847559-80-2 | Medchem Express | VER-82576 | 5mg | 446259570 | HY-10942 | MFCD18251568 | 480.41 | C21H23Cl2N5O2S
Medchem Express | VER-82576 | 5mg | 446259570 | HY-10942 | 847559-80-2 | MFCD18251568 | 480.410 | C21H23Cl2N5O2S
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eMolecules 1213016-49-9 | (2S)-2-AMINO-2-(3-METHOXYPHENYL)ETHAN-1-OL | MFCD09253686 | 1g
Ambeed | 2-Fluoroisonicotinaldehyde | 250mg | 525166551 | A274455 | 131747-69-8 | MFCD06410677 | 125.102 | C6H4FNO
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5000380402 2 -ETHYL SIMVASTATIN 2.5MG
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MEDCHEMEXPRESS LLC PROTAC BET DEGRADER-2 5MG
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501872511 PROTAC BET DEGRADER-2 5MG
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5000430132 ETHYL EOSIN 25MG
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5000872772 1-FLUORO-3- 1-METHYLPROPYL TH
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5000734442 ARIPIPRAZOLE IMPURIT 250MG
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